Abstract
Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We conducted an animal seroprevalence meta-analysis using a random effects model. We compiled gran-ular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. Overall, 57 studies were eligible out of 1523 screened, published between the years 1961 and 2020. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquil-lettidia, and Sabethes. Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Among non-human vertebrates, the Primate order had the highest pooled seroprevalence at 13.1% (95% CI: 4.3–25.1%). From the three most studied primate genera we found the highest seroprevalence was in Alouatta (32.2%, 95% CI: 0.0–79.2%), followed by Callithrix (17.8%, 95% CI: 8.6–28.5%), and Cebus/Sapajus (3.7%, 95% CI: 0.0–11.1%). We further found that MAYV occurs in a wide range of vectors beyond Haemagogus spp. The quality of evidence behind these findings was variable and prompts calls for standardization of reporting of arbovirus occurrence. These findings support further risk emergence prediction, guide field surveillance efforts, and prompt further in-vivo studies to better define the ecological drivers of MAYV maintenance and potential for emergence.
Original language | English |
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Article number | e0010016 |
Journal | PLoS Neglected Tropical Diseases |
Volume | 15 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2021 |
Externally published | Yes |
Funding
A.A.’s participation in this work was supported by funding from Armed Forces Health Surveillance Branch-Global Emerging Infections Surveillance (GEIS) Project #P0044_20_NS and NASA Applied Sciences Program – Health and Air Quality, Grant #17-HAQ17-0065. S.P.’s participation in this work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, https:// www.niaid.nih.gov/, under Inter-Agency Agreement Y1-AI-5072, and the Defense Health Program, U.S. DoD, under award HU0001190002. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funders | Funder number |
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Defense Health Program | |
U.S. DoD | HU0001190002 |
National Institutes of Health | |
National Institute of Allergy and Infectious Diseases | N01AI005072 |
National Aeronautics and Space Administration | 17-HAQ17-0065 |
Armed Forces Health Surveillance Branch | 0044_20_NS |