A 224Ra-labeled polyoxopalladate as a putative radiopharmaceutical

Matthew Gott; Peng Yang; Ulrich Kortz; Holger Stephan; Hans Jürgen Pietzsch; Constantin Mamat

doi:10.1039/c9cc02587a

A ²²⁴Ra-labeled polyoxopalladate as a putative radiopharmaceutical

Matthew Gott, Peng Yang, Ulrich Kortz, Holger Stephan, Hans Jürgen Pietzsch, Constantin Mamat

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Despite their attractive properties, internal targeted alpha therapies using ^223/224Ra are limited to bone-seeking applications. As there is no suitable chelator available, the search for new carriers to stably bind Ra²⁺ and to connect it to biological target molecules is necessary. Polyoxopalladates represent a class of compounds where Ra²⁺ can be easily introduced into the Pd-POM core during a facile one-pot preparation. Due to the formation of a protein corona, the connection to other targeting (bio)macromolecules is possible.

Original language	English
Pages (from-to)	7631-7634
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	53
DOIs	https://doi.org/10.1039/c9cc02587a
State	Published - 2019
Externally published	Yes

Funding

Ulrich Kortz acknowledges the German Science Foundation (DFG, KO-2288/20-1, KO-2288/16-1) and Jacobs University for research support. Peng Yang thanks the China Scholarship Council (CSC) for a doctoral fellowship.

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10.1039/c9cc02587a

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title = "A 224Ra-labeled polyoxopalladate as a putative radiopharmaceutical",

abstract = "Despite their attractive properties, internal targeted alpha therapies using 223/224Ra are limited to bone-seeking applications. As there is no suitable chelator available, the search for new carriers to stably bind Ra2+ and to connect it to biological target molecules is necessary. Polyoxopalladates represent a class of compounds where Ra2+ can be easily introduced into the Pd-POM core during a facile one-pot preparation. Due to the formation of a protein corona, the connection to other targeting (bio)macromolecules is possible.",

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AU - Yang, Peng

AU - Kortz, Ulrich

AU - Stephan, Holger

AU - Pietzsch, Hans Jürgen

AU - Mamat, Constantin

PY - 2019

Y1 - 2019

N2 - Despite their attractive properties, internal targeted alpha therapies using 223/224Ra are limited to bone-seeking applications. As there is no suitable chelator available, the search for new carriers to stably bind Ra2+ and to connect it to biological target molecules is necessary. Polyoxopalladates represent a class of compounds where Ra2+ can be easily introduced into the Pd-POM core during a facile one-pot preparation. Due to the formation of a protein corona, the connection to other targeting (bio)macromolecules is possible.

AB - Despite their attractive properties, internal targeted alpha therapies using 223/224Ra are limited to bone-seeking applications. As there is no suitable chelator available, the search for new carriers to stably bind Ra2+ and to connect it to biological target molecules is necessary. Polyoxopalladates represent a class of compounds where Ra2+ can be easily introduced into the Pd-POM core during a facile one-pot preparation. Due to the formation of a protein corona, the connection to other targeting (bio)macromolecules is possible.

UR - https://www.scopus.com/pages/publications/85068118850

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ER -

A ²²⁴Ra-labeled polyoxopalladate as a putative radiopharmaceutical

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