A restraint-free small animal SPECT imaging system with motion tracking

A. G. Weisenberger; S. S. Gleason; J. Goddard; B. Kross; S. Majewski; S. R. Meikle; M. J. Paulus; M. Pomper; V. Popov; M. F. Smith; B. L. Welch; R. Wojcik

doi:10.1109/TNS.2005.851399

A restraint-free small animal SPECT imaging system with motion tracking

A. G. Weisenberger, S. S. Gleason, J. Goddard, B. Kross, S. Majewski, S. R. Meikle, M. J. Paulus, M. Pomper, V. Popov, M. F. Smith, B. L. Welch, R. Wojcik

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.

Original language	English
Pages (from-to)	638-644
Number of pages	7
Journal	IEEE Transactions on Nuclear Science
Volume	52
Issue number	3 I
DOIs	https://doi.org/10.1109/TNS.2005.851399
State	Published - Jun 2005

Funding

Manuscript received November 19, 2003. The Southeastern Universities Research Association (SURA) operates the Thomas Jefferson National Accelerator Facility (Jefferson Laboratory) for the U.S. Department of Energy (DOE) under Contract DE-AC05-84ER40150. This work is supported in part by the DOE Office of Biological and Environmental Research in the Office of Science through the DOE Medical Imaging program and from the DOE Office of Nuclear Physics.

Funders	Funder number
DOE Office of Nuclear Physics
Southeastern Universities Research Association
U.S. Department of Energy	DE-AC05-84ER40150
Office of Science
Biological and Environmental Research
Thomas Jefferson National Accelerator Facility

Keywords

Motion tracking
Multimodality imaging
Small animal single photon emission computed tomography (SPECT)

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10.1109/TNS.2005.851399

Cite this

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title = "A restraint-free small animal SPECT imaging system with motion tracking",

abstract = "We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.",

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author = "Weisenberger, {A. G.} and Gleason, {S. S.} and J. Goddard and B. Kross and S. Majewski and Meikle, {S. R.} and Paulus, {M. J.} and M. Pomper and V. Popov and Smith, {M. F.} and Welch, {B. L.} and R. Wojcik",

year = "2005",

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AU - Meikle, S. R.

AU - Paulus, M. J.

AU - Pomper, M.

AU - Popov, V.

AU - Smith, M. F.

AU - Welch, B. L.

AU - Wojcik, R.

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AB - We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.

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A restraint-free small animal SPECT imaging system with motion tracking

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