Abstract
A practical and efficient H/D exchange method for selective deuteration of terminal alkynes was disclosed. The reaction was simply performed with CF3COOAg as catalyst at room temperature, affording products with high level of deuterium incorporation. The excellent site-selectivity and promising functional group tolerance of this protocol enabled deuteration of pharmaceuticals and nature product derivatives.
Original language | English |
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Article number | 152807 |
Journal | Tetrahedron Letters |
Volume | 66 |
DOIs | |
State | Published - Mar 2 2021 |
Externally published | Yes |
Funding
We thank the National Natural Science Foundation of China (Grant Numbers 21704041), Six Talent Peaks Project in Jiangsu Province (Grant Numbers XCL-027) and Nanjing Scientific Research Foundation for Returned Scholars for support. We thank Kunlun Hong (Oak Ridge National Laboratory) for assistance with the preparation of the manuscript. We thank the National Natural Science Foundation of China (Grant Numbers 21704041), Six Talent Peaks Project in Jiangsu Province (Grant Numbers XCL-027) and Nanjing Scientific Research Foundation for Returned Scholars for support. We thank Kunlun Hong (Oak Ridge National Laboratory) for assistance with the preparation of the manuscript.
Funders | Funder number |
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Nanjing Scientific Research Foundation for Returned Scholars | |
Oak Ridge National Laboratory | |
National Natural Science Foundation of China | 21704041 |
Six Talent Peaks Project in Jiangsu Province | XCL-027 |
Keywords
- Late-stage deuteration
- Silver salt
- Terminal alkyne