Abstract
Two versions of a new high-resolution x-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mammalian Genetics Research Facility. The first prototype employs a single-pixel cadmium zinc telluride detector with a pinhole collimator operating in pulse counting mode. The second version employs a phosphor screen/CCD detector operating in current mode. The major system hardware includes a low-energy x-ray tube, two linear translation stages and a rotational stage. For the single-pixel detector, image resolution is determined by the step size of the detector stage; preliminary images have been acquired at 100 Urn and 250 urn resolutions. The resolution of the phosphor screen detector is determined by tne modulation transfer function of the phosphor screen; images with resolutions approaching 50 (im have been acquired. The system performance with the two detectors is described and recent images are presented.
| Original language | English |
|---|---|
| Pages (from-to) | 558-564 |
| Number of pages | 7 |
| Journal | IEEE Transactions on Nuclear Science |
| Volume | 46 |
| Issue number | 3 PART 2 |
| DOIs | |
| State | Published - 1999 |
Funding
The Oak Ridge colony currently houses more than 70,000 mice representing about 400 mutant lines. Each time a mutagenesis experiment is performed, the mice must be screened for the presence of mutations. Typically more than 500 mice are produced for each observed phenotype. The 'Research sponsored by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by Lockheed Martin Energy Research Corp. for the U.S. Department of Energy under Contract No. DE-ACOS-