A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s

Dong Woo Lim; Seung Ho Choi; Tae Gwan Park

doi:10.1002/(sici)1521-3927(20000501)21:8<464::aid-marc464>3.0.co;2-%23

A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s

Dong Woo Lim, Seung Ho Choi, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Communication: Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2-hydroxyethyl methacrylate) (HEMA) and biodegradable oligo(L-lactide) (OLLA) or oligo(D-lactide) (ODLA) were synthesized by free radical copolymerization. HEMA-OL(D)LA macromonomers were synthesized by ring opening polymerization of L- or D-lactide. Both HEMA-OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X-ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA-g-OLLA) and poly(HEMA-g-ODLA) degraded more slowly in phosphate buffered saline than individual optically pure poly(HEMA-g-OL(D)LA).

Original language	English
Pages (from-to)	464-471
Number of pages	8
Journal	Macromolecular Rapid Communications
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/(sici)1521-3927(20000501)21:8<464::aid-marc464>3.0.co;2-%23
State	Published - May 31 2000
Externally published	Yes

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10.1002/(sici)1521-3927(20000501)21:8<464::aid-marc464>3.0.co;2-%23

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title = "A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s",

abstract = "Communication: Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2-hydroxyethyl methacrylate) (HEMA) and biodegradable oligo(L-lactide) (OLLA) or oligo(D-lactide) (ODLA) were synthesized by free radical copolymerization. HEMA-OL(D)LA macromonomers were synthesized by ring opening polymerization of L- or D-lactide. Both HEMA-OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X-ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA-g-OLLA) and poly(HEMA-g-ODLA) degraded more slowly in phosphate buffered saline than individual optically pure poly(HEMA-g-OL(D)LA).",

author = "Lim, {Dong Woo} and Choi, {Seung Ho} and Park, {Tae Gwan}",

year = "2000",

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T1 - A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s

AU - Lim, Dong Woo

AU - Choi, Seung Ho

AU - Park, Tae Gwan

PY - 2000/5/31

Y1 - 2000/5/31

N2 - Communication: Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2-hydroxyethyl methacrylate) (HEMA) and biodegradable oligo(L-lactide) (OLLA) or oligo(D-lactide) (ODLA) were synthesized by free radical copolymerization. HEMA-OL(D)LA macromonomers were synthesized by ring opening polymerization of L- or D-lactide. Both HEMA-OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X-ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA-g-OLLA) and poly(HEMA-g-ODLA) degraded more slowly in phosphate buffered saline than individual optically pure poly(HEMA-g-OL(D)LA).

AB - Communication: Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2-hydroxyethyl methacrylate) (HEMA) and biodegradable oligo(L-lactide) (OLLA) or oligo(D-lactide) (ODLA) were synthesized by free radical copolymerization. HEMA-OL(D)LA macromonomers were synthesized by ring opening polymerization of L- or D-lactide. Both HEMA-OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X-ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA-g-OLLA) and poly(HEMA-g-ODLA) degraded more slowly in phosphate buffered saline than individual optically pure poly(HEMA-g-OL(D)LA).

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SN - 1022-1336

VL - 21

SP - 464

EP - 471

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 8

ER -

A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA-g-OLA)s

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