A modified QuEChERS sample processing method for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental biological matrices

Xiaoyan Yun; Marie J. Kurz; Rominder Suri; Erica R. McKenzie

doi:10.1016/j.mex.2023.102290

A modified QuEChERS sample processing method for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental biological matrices

Xiaoyan Yun, Marie J. Kurz, Rominder Suri, Erica R. McKenzie

Biogeochemical Dynamics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample processing methods have previously been applied to a range of compounds and matrices. This study presents a modified QuEChERS sample processing method that was validated and employed for 24 per- and polyfluoroalkyl substances (PFAS) for various biological matrices. PFAS are a group of synthetic chemicals that have attracted substantial attention as some compounds are acknowledged to be persistent, toxic, and bioaccumulative. It is crucial to determine PFAS in diverse environmental matrices. Currently, limited sample processing methods for PFAS in biological matrices are available and the majority only focus on a few compounds such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Thus, there is a demand to develop a sample processing method which is effective for many commonly tested PFAS compounds in environmental biological samples. In this study, the detailed sample processing procedures and method performance are described. The highlights of this method are: • The extraction solvent and salts were adjusted for PFAS extraction from environmental biological matrices. • The modified QuEChERS method is effective for extraction and cleanup from a variety of matrices including algae, plants, invertebrates, amphibians, and fish.

Original language	English
Article number	102290
Journal	MethodsX
Volume	11
DOIs	https://doi.org/10.1016/j.mex.2023.102290
State	Published - Dec 2023

Funding

This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The publisher acknowledges the US government license to provide public access to these results in accordance with the DOE Public Access Plan ( https://energy.gov/downloads/doe-public-access-plan ). Tracey Curran and Joseph Heiczinger, both employees of the Academy of Natural Sciences of Drexel University , are thanked for their help in executing the modified QuEChERS method to process field collected samples. This work was supported by the Strategic Environmental Research and Development Program (SERDP) grant ER19-1032 , with additional support from Oak Ridge National Laboratory. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the U.S. Department of Energy . Tracey Curran and Joseph Heiczinger, both employees of the Academy of Natural Sciences of Drexel University, are thanked for their help in executing the modified QuEChERS method to process field collected samples. This work was supported by the Strategic Environmental Research and Development Program (SERDP) grant ER19-1032, with additional support from Oak Ridge National Laboratory. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the U.S. Department of Energy.

Funders	Funder number
U.S. Department of Energy
Academy of Natural Sciences of Drexel University
Oak Ridge National Laboratory
Strategic Environmental Research and Development Program	ER19-1032
UT-Battelle	DE-AC05-00OR22725

Keywords

Biological tissue samples
Contaminant extraction
Matrix interferences
PFAS analysis
Sorbents cleanup

Access to Document

10.1016/j.mex.2023.102290

Cite this

@article{6722b7f21ab2449a8a2de73db59299b8,

title = "A modified QuEChERS sample processing method for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental biological matrices",

abstract = "QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample processing methods have previously been applied to a range of compounds and matrices. This study presents a modified QuEChERS sample processing method that was validated and employed for 24 per- and polyfluoroalkyl substances (PFAS) for various biological matrices. PFAS are a group of synthetic chemicals that have attracted substantial attention as some compounds are acknowledged to be persistent, toxic, and bioaccumulative. It is crucial to determine PFAS in diverse environmental matrices. Currently, limited sample processing methods for PFAS in biological matrices are available and the majority only focus on a few compounds such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Thus, there is a demand to develop a sample processing method which is effective for many commonly tested PFAS compounds in environmental biological samples. In this study, the detailed sample processing procedures and method performance are described. The highlights of this method are: • The extraction solvent and salts were adjusted for PFAS extraction from environmental biological matrices. • The modified QuEChERS method is effective for extraction and cleanup from a variety of matrices including algae, plants, invertebrates, amphibians, and fish.",

keywords = "Biological tissue samples, Contaminant extraction, Matrix interferences, PFAS analysis, Sorbents cleanup",

author = "Xiaoyan Yun and Kurz, {Marie J.} and Rominder Suri and McKenzie, {Erica R.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = dec,

doi = "10.1016/j.mex.2023.102290",

language = "English",

volume = "11",

journal = "MethodsX",

issn = "2215-0161",

publisher = "Elsevier",

}

TY - JOUR

T1 - A modified QuEChERS sample processing method for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental biological matrices

AU - Yun, Xiaoyan

AU - Kurz, Marie J.

AU - Suri, Rominder

AU - McKenzie, Erica R.

PY - 2023/12

Y1 - 2023/12

N2 - QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample processing methods have previously been applied to a range of compounds and matrices. This study presents a modified QuEChERS sample processing method that was validated and employed for 24 per- and polyfluoroalkyl substances (PFAS) for various biological matrices. PFAS are a group of synthetic chemicals that have attracted substantial attention as some compounds are acknowledged to be persistent, toxic, and bioaccumulative. It is crucial to determine PFAS in diverse environmental matrices. Currently, limited sample processing methods for PFAS in biological matrices are available and the majority only focus on a few compounds such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Thus, there is a demand to develop a sample processing method which is effective for many commonly tested PFAS compounds in environmental biological samples. In this study, the detailed sample processing procedures and method performance are described. The highlights of this method are: • The extraction solvent and salts were adjusted for PFAS extraction from environmental biological matrices. • The modified QuEChERS method is effective for extraction and cleanup from a variety of matrices including algae, plants, invertebrates, amphibians, and fish.

AB - QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample processing methods have previously been applied to a range of compounds and matrices. This study presents a modified QuEChERS sample processing method that was validated and employed for 24 per- and polyfluoroalkyl substances (PFAS) for various biological matrices. PFAS are a group of synthetic chemicals that have attracted substantial attention as some compounds are acknowledged to be persistent, toxic, and bioaccumulative. It is crucial to determine PFAS in diverse environmental matrices. Currently, limited sample processing methods for PFAS in biological matrices are available and the majority only focus on a few compounds such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Thus, there is a demand to develop a sample processing method which is effective for many commonly tested PFAS compounds in environmental biological samples. In this study, the detailed sample processing procedures and method performance are described. The highlights of this method are: • The extraction solvent and salts were adjusted for PFAS extraction from environmental biological matrices. • The modified QuEChERS method is effective for extraction and cleanup from a variety of matrices including algae, plants, invertebrates, amphibians, and fish.

KW - Biological tissue samples

KW - Contaminant extraction

KW - Matrix interferences

KW - PFAS analysis

KW - Sorbents cleanup

UR - http://www.scopus.com/inward/record.url?scp=85166968421&partnerID=8YFLogxK

U2 - 10.1016/j.mex.2023.102290

DO - 10.1016/j.mex.2023.102290

M3 - Article

AN - SCOPUS:85166968421

SN - 2215-0161

VL - 11

JO - MethodsX

JF - MethodsX

M1 - 102290

ER -

A modified QuEChERS sample processing method for the determination of per- and polyfluoroalkyl substances (PFAS) in environmental biological matrices

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this