A model of the retention, translocation and excretion of systemic Pu

A model is developed to describe retention, translocation, and excretion of Pu that has reached the blood stream of an adult human. Emphasis has been placed on depicting the processes that govern the behavior of Pu in the body, particularly its retention in the skeleton and liver and its removal in urine and feces. Plutonium-specific information, primarily from animal studies, is used for identifying these processes. Suggested parameter values for soluble Pu are based mainly on information for humans, including general physiological and anatomical information about the compartments involved as well as data on Pu in humans. With appropriate modifications in some of the rate constants, the model is applicable to other actinides and to insoluble forms of Pu.