TY - JOUR
T1 - A genomic catalog of Earth’s microbiomes
AU - IMG/M Data Consortium
AU - Nayfach, Stephen
AU - Roux, Simon
AU - Seshadri, Rekha
AU - Udwary, Daniel
AU - Varghese, Neha
AU - Schulz, Frederik
AU - Wu, Dongying
AU - Paez-Espino, David
AU - Chen, I. Min
AU - Huntemann, Marcel
AU - Palaniappan, Krishna
AU - Ladau, Joshua
AU - Mukherjee, Supratim
AU - Reddy, T. B.K.
AU - Nielsen, Torben
AU - Kirton, Edward
AU - Faria, José P.
AU - Edirisinghe, Janaka N.
AU - Henry, Christopher S.
AU - Jungbluth, Sean P.
AU - Chivian, Dylan
AU - Dehal, Paramvir
AU - Wood-Charlson, Elisha M.
AU - Arkin, Adam P.
AU - Tringe, Susannah G.
AU - Visel, Axel
AU - Abreu, Helena
AU - Acinas, Silvia G.
AU - Allen, Eric
AU - Allen, Michelle A.
AU - Alteio, Lauren V.
AU - Andersen, Gary
AU - Anesio, Alexandre M.
AU - Attwood, Graeme
AU - Avila-Magaña, Viridiana
AU - Badis, Yacine
AU - Bailey, Jake
AU - Baker, Brett
AU - Baldrian, Petr
AU - Barton, Hazel A.
AU - Beck, David A.C.
AU - Becraft, Eric D.
AU - Beller, Harry R.
AU - Beman, J. Michael
AU - Bernier-Latmani, Rizlan
AU - Berry, Timothy D.
AU - Bertagnolli, Anthony
AU - Bertilsson, Stefan
AU - Pelletier, Dale
AU - Schadt, Christopher W.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2021/4
Y1 - 2021/4
N2 - The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.
AB - The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.
UR - http://www.scopus.com/inward/record.url?scp=85095709328&partnerID=8YFLogxK
U2 - 10.1038/s41587-020-0718-6
DO - 10.1038/s41587-020-0718-6
M3 - Article
C2 - 33169036
AN - SCOPUS:85095709328
SN - 1087-0156
VL - 39
SP - 499
EP - 509
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 4
ER -