A framework for challenges and solutions in biodesign research

Funding

We thank Dr. John Lagergren (Oak Ridge National Laboratory, Oak Ridge, Tennessee) for providing suggestions and comments on the math functions describing the relationship between challenges and solutions. We also thank Ms. Jennifer J. Michal (Department of Animal Sciences, Washington State University) for editing the manuscript. The writing of this manuscript was supported by the U.S. Department of Energy, Office of Science, Biological and Environmental Research Program, Genomic Science Program, as part of the Center for Bioenergy Innovation (CBI) under FWP ERKP886 and the Secure Ecosystem Engineering and Design (SEED) Scientific Focus Area under FWP ERKPA17. Oak Ridge National Laboratory is managed by UT-Battelle, LLC for the U.S. Department of Energy under Contract Number DE-AC05-00OR22725. This work was also supported by USDA/NIFA grants – 2022-51300-38058, 2023-67015-39566 and 2023-67015-40080 to ZJ. This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).