A Distributed Data Infrastructure for Open Bioinformatics Research

Dali Wang; Mung Shu Shen; Eric Wang; Feng Chen; Weijiao Wang

doi:10.1109/ICICT64582.2025.00073

A Distributed Data Infrastructure for Open Bioinformatics Research

Dali Wang
, Mung Shu Shen
, Eric Wang
, Feng Chen
, Weijiao Wang

Earth Systems Modeling

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper outlines a distributed data infrastructure designed to enhance open bioinformatics research, particularly in enzyme structure investigation. Utilizing high-throughput computing and cloud resources, such as AWS, the architecture facilitates collaborative workflows while ensuring robust user management, security, data integrity, and scalability. Powered by a Django backend and an Angular frontend, the infrastructure promotes seamless communication and data handling. A case study demonstrates its application in enzyme structure analysis using computational tools like AlphaFold and AlphaFill, revealing improvements in understanding enzymatic functions and accelerating drug discovery. Ultimately, this infrastructure aims to improve the efficiency and accessibility of bioinformatics research.

Original language	English
Title of host publication	Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	429-434
Number of pages	6
ISBN (Electronic)	9798331505189
DOIs	https://doi.org/10.1109/ICICT64582.2025.00073
State	Published - 2025
Event	8th International Conference on Information and Computer Technologies, ICICT 2025 - Hawaii-Hilo, United States Duration: Mar 14 2025 → Mar 16 2025

Publication series

Name	Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025

Conference

Conference	8th International Conference on Information and Computer Technologies, ICICT 2025
Country/Territory	United States
City	Hawaii-Hilo
Period	03/14/25 → 03/16/25

Funding

This work was partially supported in part by the U.S. Department of Energy, Office of Science, Office of Workforce Development for Teachers and Scientists (WDTS) under the Science Undergraduate Laboratory Internships program. This research used resources at Oak Ridge National Laboratory and the University of Tennessee, Knoxville, including those resources supported by the NIH projects (R01GM097576 and 1R01GM152927-01) that were awarded to the Memorial Sloan Kettering Cancer Center and the University of Tennessee, Knoxville.

Keywords

bioinformatics
data infrastructure
enzyme design

Access to Document

10.1109/ICICT64582.2025.00073

Cite this

Wang, D., Shen, M. S., Wang, E., Chen, F., & Wang, W. (2025). A Distributed Data Infrastructure for Open Bioinformatics Research. In Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025 (pp. 429-434). (Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICICT64582.2025.00073

Wang, Dali ; Shen, Mung Shu ; Wang, Eric et al. / A Distributed Data Infrastructure for Open Bioinformatics Research. Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025. Institute of Electrical and Electronics Engineers Inc., 2025. pp. 429-434 (Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025).

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title = "A Distributed Data Infrastructure for Open Bioinformatics Research",

abstract = "This paper outlines a distributed data infrastructure designed to enhance open bioinformatics research, particularly in enzyme structure investigation. Utilizing high-throughput computing and cloud resources, such as AWS, the architecture facilitates collaborative workflows while ensuring robust user management, security, data integrity, and scalability. Powered by a Django backend and an Angular frontend, the infrastructure promotes seamless communication and data handling. A case study demonstrates its application in enzyme structure analysis using computational tools like AlphaFold and AlphaFill, revealing improvements in understanding enzymatic functions and accelerating drug discovery. Ultimately, this infrastructure aims to improve the efficiency and accessibility of bioinformatics research.",

keywords = "bioinformatics, data infrastructure, enzyme design",

author = "Dali Wang and Shen, \{Mung Shu\} and Eric Wang and Feng Chen and Weijiao Wang",

note = "Publisher Copyright: {\textcopyright} 2025 IEEE.; 8th International Conference on Information and Computer Technologies, ICICT 2025 ; Conference date: 14-03-2025 Through 16-03-2025",

year = "2025",

doi = "10.1109/ICICT64582.2025.00073",

language = "English",

series = "Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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}

Wang, D, Shen, MS, Wang, E, Chen, F & Wang, W 2025, A Distributed Data Infrastructure for Open Bioinformatics Research. in Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025. Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025, Institute of Electrical and Electronics Engineers Inc., pp. 429-434, 8th International Conference on Information and Computer Technologies, ICICT 2025, Hawaii-Hilo, United States, 03/14/25. https://doi.org/10.1109/ICICT64582.2025.00073

A Distributed Data Infrastructure for Open Bioinformatics Research. / Wang, Dali; Shen, Mung Shu; Wang, Eric et al.
Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025. Institute of Electrical and Electronics Engineers Inc., 2025. p. 429-434 (Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A Distributed Data Infrastructure for Open Bioinformatics Research

AU - Wang, Dali

AU - Shen, Mung Shu

AU - Wang, Eric

AU - Chen, Feng

AU - Wang, Weijiao

PY - 2025

Y1 - 2025

N2 - This paper outlines a distributed data infrastructure designed to enhance open bioinformatics research, particularly in enzyme structure investigation. Utilizing high-throughput computing and cloud resources, such as AWS, the architecture facilitates collaborative workflows while ensuring robust user management, security, data integrity, and scalability. Powered by a Django backend and an Angular frontend, the infrastructure promotes seamless communication and data handling. A case study demonstrates its application in enzyme structure analysis using computational tools like AlphaFold and AlphaFill, revealing improvements in understanding enzymatic functions and accelerating drug discovery. Ultimately, this infrastructure aims to improve the efficiency and accessibility of bioinformatics research.

AB - This paper outlines a distributed data infrastructure designed to enhance open bioinformatics research, particularly in enzyme structure investigation. Utilizing high-throughput computing and cloud resources, such as AWS, the architecture facilitates collaborative workflows while ensuring robust user management, security, data integrity, and scalability. Powered by a Django backend and an Angular frontend, the infrastructure promotes seamless communication and data handling. A case study demonstrates its application in enzyme structure analysis using computational tools like AlphaFold and AlphaFill, revealing improvements in understanding enzymatic functions and accelerating drug discovery. Ultimately, this infrastructure aims to improve the efficiency and accessibility of bioinformatics research.

KW - bioinformatics

KW - data infrastructure

KW - enzyme design

UR - https://www.scopus.com/pages/publications/105010766615

U2 - 10.1109/ICICT64582.2025.00073

DO - 10.1109/ICICT64582.2025.00073

M3 - Conference contribution

AN - SCOPUS:105010766615

T3 - Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025

SP - 429

EP - 434

BT - Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 8th International Conference on Information and Computer Technologies, ICICT 2025

Y2 - 14 March 2025 through 16 March 2025

ER -

Wang D, Shen MS, Wang E, Chen F, Wang W. A Distributed Data Infrastructure for Open Bioinformatics Research. In Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025. Institute of Electrical and Electronics Engineers Inc. 2025. p. 429-434. (Proceedings - 2025 8th International Conference on Information and Computer Technologies, ICICT 2025). doi: 10.1109/ICICT64582.2025.00073

A Distributed Data Infrastructure for Open Bioinformatics Research

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