@inproceedings{5bbe69c006fb4f559514fdbc019288c8,
title = "A discrete cell migration model",
abstract = "Migration of vascular smooth muscle cells is a fundamental process in the development of intimal hyperplasia, a precursor to development of cardiovascular disease and a potential response to injury of an arterial wall. Boyden chamber experiments are used to quantify the motion of cell populations in response to a chemoattractant gradient (i.e., cell chemotaxis). We are developing a mathematical model of cell migration within the Boyden chamber, while simultaneously conducting experiments to obtain parameter values for the migration process. In the future, the model and parameters will be used as building blocks for a detailed model of the process that causes intimal hyperplasia. The cell migration model presented in this paper is based on the notion of a cell as a moving sensor that responds to an evolving chemoattractant gradient. We compare the results of our three-dimensional hybrid modelwith results from a one-dimensional continuummodel. Some preliminary experimental data that is being used to refine the model is also presented.",
keywords = "Boyden chamber, Cell migration, Chemotaxis, Discrete event simulation",
author = "James Nutaro and Kara Kruse and Richard Ward and Elizabeth O'Quinn and Matthew Woerner and Barbara Beckerman and Stacy Kirkpatrick and Deidra Mountain and Oscar Grandas",
year = "2007",
language = "English",
isbn = "9781622763580",
series = "Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07",
pages = "811--816",
booktitle = "Summer Computer Simulation Conference 2007, SCSC'07, Part of the 2007 Summer Simulation Multiconference, SummerSim'07",
note = "Summer Computer Simulation Conference 2007, SCSC 2007, Part of the 2007 Summer Simulation Multiconference, SummerSim 2007 ; Conference date: 15-07-2007 Through 18-07-2007",
}
