A combined neutron scattering and simulation study on bioprotectant systems

F. Affouard; P. Bordat; M. Descamps; A. Lerbret; S. Magazù; F. Migliardo; A. J. Ramirez-Cuesta; M. F.T. Telling

doi:10.1016/j.chemphys.2005.05.033

A combined neutron scattering and simulation study on bioprotectant systems

F. Affouard, P. Bordat, M. Descamps, A. Lerbret, S. Magazù, F. Migliardo, A. J. Ramirez-Cuesta, M. F.T. Telling

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The present work shows quasi elastic neutron scattering, neutron spin echo and inelastic neutron scattering results on a class of bioprotectant systems, such as homologous disaccharides (i.e., trehalose and sucrose)/water solutions, as a function of temperature. The whole set of findings indicates a noticeable "kosmotrope" character of the disaccharides, and in particular of trehalose, which is able to strongly modify both the structural and dynamical properties of water. This superior capability of trehalose can be linked to its higher bioprotective effectiveness in respect with the other disaccharides.

Original language	English
Pages (from-to)	258-266
Number of pages	9
Journal	Chemical Physics
Volume	317
Issue number	2-3
DOIs	https://doi.org/10.1016/j.chemphys.2005.05.033
State	Published - Oct 31 2005
Externally published	Yes

Keywords

Bioprotective effects
Disaccharides
Dynamical properties
Neutron scattering
Water mixtures

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10.1016/j.chemphys.2005.05.033

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title = "A combined neutron scattering and simulation study on bioprotectant systems",

abstract = "The present work shows quasi elastic neutron scattering, neutron spin echo and inelastic neutron scattering results on a class of bioprotectant systems, such as homologous disaccharides (i.e., trehalose and sucrose)/water solutions, as a function of temperature. The whole set of findings indicates a noticeable {"}kosmotrope{"} character of the disaccharides, and in particular of trehalose, which is able to strongly modify both the structural and dynamical properties of water. This superior capability of trehalose can be linked to its higher bioprotective effectiveness in respect with the other disaccharides.",

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T1 - A combined neutron scattering and simulation study on bioprotectant systems

AU - Affouard, F.

AU - Bordat, P.

AU - Descamps, M.

AU - Lerbret, A.

AU - Magazù, S.

AU - Migliardo, F.

AU - Ramirez-Cuesta, A. J.

AU - Telling, M. F.T.

PY - 2005/10/31

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N2 - The present work shows quasi elastic neutron scattering, neutron spin echo and inelastic neutron scattering results on a class of bioprotectant systems, such as homologous disaccharides (i.e., trehalose and sucrose)/water solutions, as a function of temperature. The whole set of findings indicates a noticeable "kosmotrope" character of the disaccharides, and in particular of trehalose, which is able to strongly modify both the structural and dynamical properties of water. This superior capability of trehalose can be linked to its higher bioprotective effectiveness in respect with the other disaccharides.

AB - The present work shows quasi elastic neutron scattering, neutron spin echo and inelastic neutron scattering results on a class of bioprotectant systems, such as homologous disaccharides (i.e., trehalose and sucrose)/water solutions, as a function of temperature. The whole set of findings indicates a noticeable "kosmotrope" character of the disaccharides, and in particular of trehalose, which is able to strongly modify both the structural and dynamical properties of water. This superior capability of trehalose can be linked to its higher bioprotective effectiveness in respect with the other disaccharides.

KW - Bioprotective effects

KW - Disaccharides

KW - Dynamical properties

KW - Neutron scattering

KW - Water mixtures

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DO - 10.1016/j.chemphys.2005.05.033

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VL - 317

SP - 258

EP - 266

JO - Chemical Physics

JF - Chemical Physics

IS - 2-3

ER -

A combined neutron scattering and simulation study on bioprotectant systems

Abstract

Keywords

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