A biokinetic model for systemic technetium in adult humans

R. Leggett, A. Giussani

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This paper reviews biokinetic data for technetium and proposes a biokinetic model for systemic technetium in adult humans. The development of parameter values focuses on data for pertechnetate (TcO-4) the most commonly encountered form of technetium and the form expected to be present in body fluids. The model is intended as a default model for occupational or environmental intake of technetium i.e. applicable in the absence of form- or site-specific information. Tissues depicted explicitly in the model include thyroid salivary glands stomach wall right colon wall liver kidneys and bone. Compared with the CRP's current biokinetic model for occupational or environmental intake of technetium (CRP 1993 1994) the proposed model provides a more detailed and biologically realistic description of the systemic behaviour of technetium and is based on a broader set of experimental and medical data. For acute input of 99mTc (T1/2 = 6.02 h) to blood the ratios of cumulative (time-integrated) activity predicted by the current CRP model to that predicted by the proposed model range from 0.4-7 for systemic regions addressed explicitly in both models. For acute input of 99Tc (T1/2 = 2.1 × 105 year) to blood the corresponding ratios range from 0.2-30.

Original languageEnglish
Article number297
Pages (from-to)297-315
Number of pages19
JournalJournal of Radiological Protection
Volume35
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Biokinetics
  • Model
  • Pertechnetate
  • Systemic
  • Technetium

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