A Biokinetic Model for Systemic Nickel

Dunstana R. Melo; Richard W. Leggett

doi:10.1097/HP.0000000000000579

A Biokinetic Model for Systemic Nickel

Dunstana R. Melo, Richard W. Leggett

Environmental Risk and Energy Analysis

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP's current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59 Ni and 63 Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.

Original language	English
Pages (from-to)	18-27
Number of pages	10
Journal	Health Physics
Volume	112
Issue number	1
DOIs	https://doi.org/10.1097/HP.0000000000000579
State	Published - Jan 1 2017

Keywords

International Commission on Radiological Protection
biokinetics
nickel
radiation protection

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10.1097/HP.0000000000000579

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A Biokinetic Model for Systemic Nickel

Abstract

Keywords

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