A biokinetic model for Rb in humans

R. W. Leggett, L. R. Williams

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Although whole-body retention of Rb in humans has been characterized reasonably well, current biokinetic models for Rb do not provide detailed or accurate descriptions of the time-dependent distribution of this element within the body. In this paper we construct a physiologically descriptive biokinetic model that closely tracks the movement of Rb from the time of intake until virtually all of the ingested or injected quantity has been removed from the body. The selection process for model parameter values is described for a reference adult male, but we demonstrate how the model may be applied to non-reference humans, including young children. It is shown that the model accurately predicts long-term retention of Rb in both sexes and in different age groups and depicts changes with time in the internal distribution of Rb with sufficient accuracy to be suitable for dosimetric estimates even for the short-lived isotope 82Rb (T½ = 75 s).

Original languageEnglish
Pages (from-to)685-702
Number of pages18
JournalHealth Physics
Volume55
Issue number4
DOIs
StatePublished - Oct 1988

Fingerprint

Dive into the research topics of 'A biokinetic model for Rb in humans'. Together they form a unique fingerprint.

Cite this