Abstract
A systemic biokinetic model is presented for radiocarbon taken into the body as carbon dioxide or bicarbonate. Parameter values describing retention and excretion of carbon during the first few weeks after administration are based on studies of the fate of radiocarbon in human subjects after injection of labelled bicarbonate or inhalation of carbon dioxide. Data on laboratory animals administered labelled bicarbonate, carbonate or carbon dioxide provide information on the tissue distribution and long-term retention of carbon. Model predictions of the time-dependent distribution and retention of carbon differ considerably from those of models recommended by the International Commission on Radiological Protection.
| Original language | English |
|---|---|
| Pages (from-to) | 203-213 |
| Number of pages | 11 |
| Journal | Radiation Protection Dosimetry |
| Volume | 108 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2004 |
Funding
This work was sponsored by the Office of Radiation and Indoor Air, US Environmental Protection Agency (EPA), under Interagency Agreement DOE No. 1824-C148-A1, under contract DE-AC05-84OR21400 with UT-Battelle. The submitted manuscript has been authored by a contractor of the US Government under contract No. DE-AC05-00OR22725. Accordingly, the US Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for US Government purposes. The author is grateful to J. S. Puskin of the EPA Office of Radiation and Indoor Air for pointing out the need for this study and providing helpful reviews of the manuscript, and to R. B. Richardson of Atomic Energy of Canada Limited, Chalk River Laboratories, for helpful discussions of the manuscript.
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