TY - JOUR
T1 - 2,2′-bis(monoacylglycero) PO4 (BMP), but not 3,1′-BMP, increases membrane curvature stress to enhance α-tocopherol transfer protein binding to membranes
AU - Baptist, Matilda
AU - Panagabko, Candace
AU - Nickels, Jonathan D.
AU - Katsaras, John
AU - Atkinson, Jeffrey
N1 - Publisher Copyright:
© 2015 AOCS.
PY - 2015/3
Y1 - 2015/3
N2 - Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. We examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. α-TTP binds to membranes with greater affinity when they contain the 2,2′-BMP versus 3,1′-BMP isomers.
AB - Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. We examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. α-TTP binds to membranes with greater affinity when they contain the 2,2′-BMP versus 3,1′-BMP isomers.
KW - Bis(monoacylglycero)phosphate
KW - Membrane curvature
KW - Vitamin E
KW - α-Tocopherol transfer protein
UR - http://www.scopus.com/inward/record.url?scp=84925506079&partnerID=8YFLogxK
U2 - 10.1007/s11745-015-3989-9
DO - 10.1007/s11745-015-3989-9
M3 - Article
C2 - 25603781
AN - SCOPUS:84925506079
SN - 0024-4201
VL - 50
SP - 323
EP - 328
JO - Lipids
JF - Lipids
IS - 3
ER -