Identification and functional characterisation of genomic enhancers in the human brain: a steppingstone to clinical translation of genetic data for brain disorders.

The genetic basis of brain disorders is incompletely understood. An important discovery over the last decade was that genetic variants associated with brain disorders are likely to impact gene expression regulation. The proposed project studies enhancers, the key regulatory elements of the genome that turn genes on and off. The project aims to identify enhancers that play functional roles in brain cells, thereby uncovering how genetic changes lead to brain disorders.