Project Details
Description
Project Summary
The mechanisms underpinning heterogeneous metabolic response between individual cells remain poorly
understood, though such mechanisms have ramifications across nearly all of medicine, e.g., disease detection,
response to stress, treatment, and more. Intracellular small molecule metabolite, lipid and therapeutic
concentrations are often inferred through protein expression or directly measured as the average of 1000’s of
cells at once, providing only a population-level view of heterogeneous metabolic response. This obfuscates
differentiation of anomalous metabolic cell phenotypes and small molecule associations occurring within cells.
Currently there exists a gap in analytical technologies for the measure of small molecules (
Status | Active |
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Effective start/end date | 09/24/22 → 07/31/25 |
Funding
- National Institute of General Medical Sciences
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